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目的：对比腹部外伤合并颅脑创伤男性患者与单纯腹部外伤男性患者的血清孕酮值，探讨其临床变化意义。方法收入我院2013年1月至11月急诊外科收治的急性腹部创伤男性患者116例，分成腹部外伤合并颅脑损伤组及单纯性腹部外伤组，并以 ISS（创伤严重度评分）分值评价创伤患者机体损伤的严重程度。另选40例健康成年男性为对照组。于伤后后12、24、36、48h行放射免疫双抗体沉淀法测定血清孕酮水平，并进行数据比较。结果两组患者均随腹部外伤的ISS评分增高，早期血清孕酮值相比对照组越高（P＜0.05）。但合并颅脑损伤组在相同ISS评分、相同时间点下早期血清孕酮值相比非颅脑损伤患者有明显升高，具有统计学意义（P＜0.05）。结论血清孕酮在急性颅脑损伤中可作为一种特异性临床指标，指示患者的脑功能损伤严重程度，提供一定的基础临床资料。“,”Objective To compare the serum progesterone in male patients with abdominal trauma combined with brain injury in male patients with abdominal trauma,explore the clinical significance of changes.Methods Recruiting qualified patients 116 cases from 2013 January to November in emergency department and divided them into the group of abdominal injury combined with craniocelebral trauma and the group of single abdominal injury,taking ISS(injury severity score)severity evaluation of trauma patients body damage.Choose another 40 healthy adult males as control group.After the injury after 12,24,36,48h radioimmunoassay double antibody precipitation method to determine serum progesterone levels,and compare the data.Results Two groups of patients with abdominal trauma in early ISS score,serum progesterone values compared to the control group higher(P<0.05).But compare to the single abdominal injury group,the other group has more significant high values in progesterone at each moment in the same ISS level(P<0.05).Conclusion The serum progesterone can be a specifical y clinical standard to measure the degree of craniocelebral trauma and providing efficient clinical data.