论文部分内容阅读
采用Wistar大鼠中毒性模型和人血白蛋白免疫性肝损害模型进行软肝合剂的抗肝纤维化研究。结果软肝合剂组中血清ALT、AST均明显低于两种病理组,光镜观察仅见轻微炎性变,而病理组的碎屑性坏死、桥形坏死甚至假小叶形成为主要病变。软肝组肝内胶原检测接近正常组,明显低于病理组,电镜观察Diss腔内仅见少量贮脂细胞以及少量微纤维沉积。提示软肝合剂在预防试验中可明显减少肝纤维化、肝硬化形成率,在治疗试验中可减少肝内胶原沉积,并出现修复性肝细胞结构。
The hepatic fibrosis of Ruan Gan He Mixture was studied using the Wistar Rat Toxicity Model and the Human Hemoalbumin Immunological Liver Damage Model. Results The serum ALT and AST levels in Ruan Gan mixture group were significantly lower than those in the two pathological groups. Mild inflammatory changes were observed by light microscopy. Destructive necrosis, bridging necrosis, and even false leaflets formed in the pathological group were the main lesions. The hepatic collagen detection in soft liver group was close to the normal group, which was significantly lower than that in the pathological group. Electron microscopy revealed that only a small amount of fat-storing cells and a small amount of microfibrils were deposited in the Diss cavity. It is suggested that Ruangan Mixture can significantly reduce the rate of hepatic fibrosis and cirrhosis in the prevention experiment. In the treatment experiment, the liver collagen deposition can be reduced, and the repaired hepatocyte structure appears.