Pattern recognition receptor (PRR) is a kind of sensor which is mainly expressed on the surface of innate immune cells. It can recognize pathogen related molecular patterns (PAMPs) or damage related molecular patterns (DAMPs). The innate immune system uses pattern recognition receptors to recognize pathogenic microorganisms in periodontal tissues and transmit signals to downstream pathways in time, thus triggering immune responses and then eliminating them. PRR has many family members, including toll like receptor family (TLRs), C-type lectin receptor family (CLRs), retinoic acid induced gene I (RIG-I) like receptor family (RLRs) and nucleotide binding oligomer domain (NOD) like receptor family (NLRs). Among them, RLRs are cytoplasmic receptors that recognize dsRNA from RNA viruses and have little association with chronic periodontitis. In this paper, the classification and structure of TLRs, CLRs, NLRs and the role of signal transduction pathway in chronic periodontitis are reviewed. In order to enrich the pathogenesis of periodontitis, provide new ideas for the treatment and prevention of chronic periodontitis.