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目的:真菌引起的疾病称为真菌病。真菌种类很多,与细菌相比,对人致病者相对较少,约270种。近年来由于广谱抗生素、肾上腺皮质激素和免疫抑制剂的大量应用,真菌感染有明显增长的趋势。真菌病根据病变部位不同可分成浅部真菌病和深部真菌病两大类。浅部真菌病主要侵犯含有角质的组织,如皮肤、毛发和指甲等处,引起各种癣病。深部真菌病侵犯皮肤深层和内脏,如肺、脑、消化道等器官,危害性较大。因深部真菌感染率的逐年上升、治疗的难度、真菌的抗药性、现有药物的毒副作用等因素存在,使得人们仍在不断寻找高效低毒的抗真菌药物。中药有副作用小、来源广、价格低廉、较少出现耐药等优点,研究开发抗真菌中药具备良好前景。本实验对32味中药的抗真菌活性进行筛选,找到其中体外抑真菌效果好的中药,为进一步研究中药抑菌机制及临床发挥中医药特色治疗微生物感染性疾病提供实验依据。
Purpose: The disease caused by fungi is called fungal disease. Many fungal species, compared with bacteria, relatively few human pathogenic, about 270 species. In recent years due to the extensive use of broad-spectrum antibiotics, adrenal hormones and immunosuppressive agents, fungal infections have a clear trend of growth. According to the different parts of the lesion can be divided into superficial mycosis and fungal mycosis two broad categories. Superficial mycosis mainly affects tissues containing keratin, such as the skin, hair and nails, causing a variety of ringworm diseases. Deep mycosis invades the skin deep and visceral, such as lung, brain, digestive tract and other organs, more harmful. Due to the increasing rate of deep fungal infections, the difficulty of treatment, the resistance of fungi and the toxicity and toxicity of existing drugs, people are still searching for antifungal drugs with high efficiency and low toxicity. Chinese medicine has the advantages of small side effects, wide sources, low prices, less resistance, research and development of antifungal Chinese medicine has good prospects. In this experiment, the antifungal activity of 32 Chinese herbs was screened to find out the traditional Chinese medicine, which has a good fungistatic effect in vitro, providing experimental basis for further studying the antimicrobial mechanism of traditional Chinese medicine and exerting the characteristic treatment of microbial infectious diseases with traditional Chinese medicine.