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目的探讨肝硬化并发自发性细菌性腹膜炎(SBP)的临床特点,腹水病原菌分布及其对抗菌药物的敏感性,为临床合理有效使用抗菌药物提供科学依据。方法回顾性分析我院近5年来54例肝硬化并发SBP患者的临床表现、病原学检查,药敏试验结果。结果 54例肝肝硬化患者临床表现多样,腹水细菌培养阳性率低,革兰阴性菌占82,其中大肠埃希菌最高(46.2)。结论肝硬化患者并发SBP病原菌以革兰阴性菌为主,早期诊断、及时足量地使用有效的抗生素治疗是改善晚期肝病患者预后的主要因素。
Objective To investigate the clinical features of cirrhotic patients with spontaneous bacterial peritonitis (SBP), the distribution of bacterial pathogens in ascites and their sensitivity to antimicrobial agents, and to provide a scientific basis for rational and effective use of antimicrobial agents in clinical practice. Methods Retrospective analysis of 54 cases of liver cirrhosis complicated with SBP in our hospital in recent 5 years clinical manifestations, etiological examination, drug sensitivity test results. Results The clinical manifestations of 54 patients with liver cirrhosis were diverse. The positive rate of bacterial culture in ascites was low. Gram-negative bacteria accounted for 82, of which Escherichia coli was the highest (46.2). Conclusions Patients with liver cirrhosis complicated with pathogenic bacteria of SBP are mainly Gram-negative bacteria. Early diagnosis, timely and adequate use of effective antibiotics are the main factors to improve the prognosis of patients with advanced liver disease.