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在电刺激伴有心肌局部损伤性缺血兔的右侧下丘脑背内侧核,合并下丘脑近视束旁前区诱发室性早搏的动物模型上,观察到东莨菪碱对实验性室性早搏具有抑制作用。这种抑制作用包括两个方面,即对切断迷走神经后不能诱发的迷走型室性早搏与切断迷走神经后仍能诱发的交感型室性早搏均有抑制作用。东莨菪碱对二侧迷走神经切断后静脉注射去甲肾上腺素使局部缺血心脏诱发的室性早搏亦有抑制作用.抑制作用的机制可能与东莨菪碱能阻断心肌胆碱能M—受体与心血管肾腺能α—受体有关。但对心肌肾腺能α—受体的抑制作用及其与心律失常的关系,尚待进一步研究。
In the animal model of electrical stimulation of right dorsal hypothalamic nucleus and premature ventricular contractions induced by hypothalamic nearsightedness in rabbits with myocardial ischemic injury, scopolamine was found to have an inhibitory effect on experimental premature ventricular contractions . This inhibitory effect includes two aspects, namely, the vagus nerve can not be induced after the closure of vagal premature ventricular contraction and vagus nerve can still be induced after sympathetic premature ventricular contraction are inhibited. Scopolamine on bilateral vagus nerve transection after intravenous injection of norepinephrine to ischemic ventricular premature ventricular contractions induced also inhibited the mechanism of inhibition may be associated with scopolamine can block the cardiac cholinergic M-receptor and cardiovascular Glandular alpha-receptor related. However, the inhibitory effect of α -receptor on cardiac kidney and its relationship with arrhythmia remains to be further studied.