自从1956年Sultherland发现环一磷酸腺苷(CAMP)以来,对激素作用原理的研究有了较大的进展。现已证实含氮类(蛋白质和肽类)激素作用于靶细胞后是通过CAMP作为媒介而起作用的。Sultherland由此提出了第二信使学说,把激素称为第一信使,而在激素的作用下靶细胞所产生的CAMP称为第二信使。同时也发现类固醇激素则是进入细胞浆后,先和某种受体蛋白相结合,生成“激素受体复合物”起作用的。 Since Sultherland discovered cyclic adenosine monophosphate (CAMP) in 1956, much progress has been made on the mechanism of action of hormones. It has been demonstrated that nitrogen-containing hormones (proteins and peptides) act via CAMP as a mediator after their action on target cells. Sultherland thus proposed the second messenger theory, the hormone called the first messenger, and hormones produced by the target cell CAMP called the second messenger. Also found that steroid hormones are into the cytoplasm, the first combination with a receptor protein, the formation of “hormone receptor complex” role.