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喉癌是头颈部恶性肿瘤中较常见的肿瘤,男性发病率是女性的10倍,近几年来喉癌发病有明显的增高趋势。研究已表明吸烟、饮酒、HPV(人类乳头状瘤病毒)感染是导致喉癌的高危因素,此外遗传因素在喉癌发病中的作用也逐步得到认识。原癌基因,如ras、c-Myc、表皮生长因子(EGF)基因受体等,抑癌基因,如p53、nm23-H1、p16、Rb基因等,与细胞凋亡有关的基因bcl-2基因与喉癌的发病过程均有密切的关系。Myc族基因扩增同多种肿瘤的发生有密切关系,Spandidos报道,在人类头颈部肿瘤中(包括喉癌)有Myc基因的表达升高,但未系统阐明喉癌Myc基因的扩增特点。近年来研究表明Myc基因与细胞凋亡有关,在参与凋亡的过程中与p53、Bcl-2有相互作用。探讨Myc基因家族与
Laryngeal cancer is a more common head and neck cancer tumors, the incidence of males is 10 times that of women in recent years, the incidence of laryngeal cancer increased significantly. Studies have shown that smoking, drinking, HPV (human papillomavirus) infection is a risk factor for laryngeal cancer, in addition to genetic factors in the pathogenesis of laryngeal cancer has gradually been recognized. Proto-oncogenes, such as ras, c-Myc, epidermal growth factor (EGF) gene receptor, tumor suppressor genes such as p53, nm23-H1, p16 and Rb genes, and apoptosis-related genes bcl- And the incidence of laryngeal cancer are closely related. Myc gene amplification is closely related to the occurrence of multiple tumors. Spandidos reported that Myc gene expression was increased in human head and neck tumors (including laryngeal cancer), but the amplification characteristics of Myc gene in laryngeal cancer were not systematically elucidated . In recent years, studies have shown that Myc gene and apoptosis, involved in the process of apoptosis with p53, Bcl-2 interaction. Explore the Myc gene family and