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目的:观察甘精胰岛素联合二甲双胍治疗2型糖尿病的临床疗效。方法:口服二甲双胍500mg,3次/日。甘精胰岛素睡前1次注射,初剂量10U/日,直至FBG≤7.0mmol/L。结果:治疗13周后患者的FPG、2小时PG以及HbA1c水平较治疗前明显降低(P<0.05),BMI与治疗前比较无明显差异(P>0.05)。结论:甘精胰岛素联合二甲双胍治疗2型糖尿病患者有效,且低血糖危险低,体重增加少。
Objective: To observe the clinical efficacy of insulin glargine and metformin in the treatment of type 2 diabetes mellitus. Methods: metformin 500mg, 3 times / day. Glargine 1 bedtime injection, the initial dose of 10U / day, until FBG ≤ 7.0mmol / L. Results: After 13 weeks of treatment, the levels of FPG, PG and HbA1c in 2 hours were significantly lower than those before treatment (P <0.05). There was no significant difference between BMI and before treatment (P> 0.05). Conclusion: Glargine and metformin are effective in treating type 2 diabetes mellitus, with low risk of hypoglycaemia and little weight gain.