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目的探讨奥扎格雷钠和低分子肝素及阿斯匹林对非ST段抬高急性冠脉综合征的疗效。方法采用单盲,随机将76例患者分为治疗组与对照组,奥扎格雷钠80mg静脉滴注,连续7d,阿斯匹林0.3g,1次/d,1周后改为0.1g,1次/d,低分子肝素5000U皮下注射,2次/d,共7d,主要终点为30d内病死率和心肌梗死发生率。结果治疗组36例,对照组40例,30d内病死率差异有显著性,对心绞痛有较好的疗效,并能降低急性心肌梗死发生率降低。结论奥扎格雷钠治疗非ST段抬高急性冠脉综合征可降低心绞痛和急性心肌梗死发生率。
Objective To investigate the effect of ozagrel sodium, low molecular weight heparin and aspirin on non-ST segment elevation acute coronary syndrome. Methods A single blind, randomized 76 patients were divided into treatment group and control group. Ozagrel sodium 80 mg was intravenously dripped continuously for 7 days, aspirin 0.3g, once a day, then to 0.1g after one week. 1 times / d, low molecular weight heparin 5000U subcutaneous injection, 2 times / d, a total of 7d, the main end point for the 30d mortality and myocardial infarction incidence. Results 36 cases in the treatment group and 40 cases in the control group showed significant differences in the case fatality rate within 30 days, better curative effect on angina pectoris, and lower the incidence of acute myocardial infarction. Conclusion Ozagrel sodium treatment of non-ST segment elevation acute coronary syndrome can reduce the incidence of angina pectoris and acute myocardial infarction.