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本文应用体外肾小球系膜细胞培养和免疫组化染色技术,以增殖细胞核抗原(PCNA)为标志抗原,观察了大黄素对肾小球系膜细胞周期调控的影响。发现大黄素能明显抑制系膜细胞从G_1期进入S期,同时对已进入S期细胞的进一步过渡也有影响。
In this paper, in vitro glomerular mesangial cell culture and immunohistochemical staining techniques, using proliferating cell nuclear antigen (PCNA) as a marker antigen, observed the effect of emodin on the cell cycle regulation of glomerular mesangial cells. It was found that emodin can significantly inhibit the mesangial cells from entering the S phase from the G1 phase, and also affect the further transition to the S phase cells.