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目的探讨125Ⅰ放射粒子在治疗中晚期胰腺癌中的疗效和安全性。方法对住院的48例中晚期胰腺癌患者进行分组。23例行125Ⅰ放射粒子植入加胆道空肠吻合内引流术,25例行胆肠吻合术,并行统计学分析。结果二组患者肝功能和胆红素均明显改善,肿瘤大小无明显变化,粒子植入组腹痛、腰痛明显减轻,二组患者并发症无明显差异。粒子植入组生存期明显延长。结论125Ⅰ放射粒子在治疗中晚期胰腺癌时安全有效。
Objective To investigate the efficacy and safety of 125 Ⅰ radioactive particles in the treatment of advanced pancreatic cancer. Methods 48 hospitalized patients with advanced pancreatic cancer were divided into groups. 23 cases of 125 Ⅰ radioactive particle implantation plus biliary jejunostomy drainage, 25 cases of choledochojejunostomy, parallel statistical analysis. Results The liver function and bilirubin were significantly improved in both groups, with no significant changes in tumor size. The abdominal pain and lumbago in the group of implanted particles were significantly reduced. There was no significant difference in the complication between the two groups. Survival of particles implantation group was significantly prolonged. Conclusion 125 Ⅰ radioactive particles in the treatment of advanced pancreatic cancer is safe and effective.