目的探讨经肛门痔上黏膜环切术(procedure for prolapse and hemorrhoids,PPH)偏心性切除吻合治疗直肠良性肿瘤伴抑郁的效果。方法选取2012年6月到2014年6月住院接受治疗的104例良性肿瘤伴抑郁患者为研究对象,随机数表法分为对照组(50例)与观察组(54例),对照组行传统肛门手术治疗,观察组行经肛门PPH偏心性切除吻合术,比较两组患者的治疗有效率及术后并发症情况。结果治疗后3个月,两组患者病情均好转,观察组的总有效率为96.30%,显著高于对照组的84.0%(P<0.05);观察组患者的术后恢复时间(平均为6.32天)和术后疗效评分(平均为9.36分)均显著优于对照组患者(术后恢复时间平均为10.87天、术后疗效美分平均为7.13分)(P<0.05)。两组患者治疗前的抑郁自评量表(SDS)及焦虑自评量表(SAS)评分相似;其治疗后的SDS及SAS评分明显高于治疗前,且治疗后观察组患者SDS及SAS评分明显低于对照组(P<0.05)。结论对于直肠良性肿瘤伴抑郁患者,肛门PPH偏心性切除吻合治疗在其恢复速度、术后并发症及抑郁改善等方面明显优于传统的手术治疗,可能有重要的临床推广价值。 Objective To investigate the effect of denervated rectal benign tumor with depression by eccentric resection and anastomosis of the procedure for prolapse and hemorrhoids (PPH). Methods A total of 104 patients with benign tumor and depression undergoing inpatient treatment from June 2012 to June 2014 were selected as the research object. The random number table was divided into control group (50 cases) and observation group (54 cases) Anal surgery, the observation group underwent anal PPH eccentric resection and anastomosis, the two groups of patients compared the efficiency of treatment and postoperative complications. Results Three months after treatment, the patients in both groups had better symptoms. The total effective rate in the observation group was 96.30%, significantly higher than that in the control group (84.0%, P <0.05). The recovery time in the observation group was 6.32 Day) and postoperative curative effect (average 9.36) were significantly better than those in the control group (average postoperative recovery time was 10.87 days, mean postoperative cents was 7.13) (P <0.05). SDS and SAS scores before treatment were similar in both groups. SDS and SAS scores after treatment were significantly higher than those before treatment, and after treatment, the SDS and SAS scores Significantly lower than the control group (P <0.05). Conclusions For patients with benign rectal neoplasms and depression, eccentric PPH anomalous resection and anastomosis treatment is obviously superior to traditional surgical treatment in terms of its recovery speed, postoperative complications and improvement of depression, and may have important clinical promotion value.