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目的 研究肝细胞癌 (HCC)组织中细胞凋亡抑制因子survivin和细胞周期素D1(cyclinD1)的表达及其意义。方法 免疫组织化学方法检测 61例HCC组织survivin和cyclinD1的表达 ,分析两指标与HCC生物学行为的关系。结果 survivin和cyclinD1的阳性率分别为 44 3 %和 3 9 3 % ;低分化组HCC两指标的阳性率均明显高于高分化组 (P <0 0 5 ) ;两指标之间呈高度正相关 (P <0 0 0 1)。结论 survivin和cyclinD1促进HCC的生长 ,两者在其中协同起作用
Objective To investigate the expression and significance of survivin and cyclin D1 in hepatocellular carcinoma (HCC). Methods Immunohistochemical method was used to detect the expression of survivin and cyclinD1 in 61 HCC tissues. The relationship between the two indexes and the biological behavior of HCC was analyzed. Results The positive rates of survivin and cyclinD1 were 44 3% and 393% respectively. The positive rate of HCC in the poorly differentiated group was significantly higher than that in the well-differentiated group (P <0 05). There was a highly positive correlation between the two indicators. (P < 0 0 0 1). Conclusions Survivin and cyclinD1 promote the growth of HCC, and both of them act synergistically.