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IgE是与变应性疾病有关的抗体。这种抗体大部分固定在发生反应的特定器官组织内,血清IgE测定并不包括组织内的IgE。在血清内,IgE的半存留期约为2天;因此特异性抗体的含量随抗原的接触和脱离而消失。在变应原中有一些能更有效地激发IgE合成,例如接触莠和草的花粉较之接触尘土、霉菌和毛皮脱屑常能产生更高含量的总的和特异性IgE抗体。总之,血清IgE测定象鼻分泌物涂片嗜酸性细胞检查一样,有助于证实变应性鼻炎的临床印象,但它只是一个指征,当然不是变应性疾病的诊断标准。
IgE is an allergic disease-related antibody. Most of this antibody is immobilized in a specific organ tissue under reaction, and the serum IgE assay does not include IgE in the tissue. In serum, the half-life of IgE is about 2 days; therefore the amount of specific antibody disappears with the contact and detachment of the antigen. Some of the allergens are more capable of stimulating IgE synthesis. For example, pollen contact with herb and grass often produces higher levels of total and specific IgE antibodies than dust, mold and fur scaling. In summary, serum IgE assays, like nasal secretions smear-like eosinophils, are helpful in confirming the clinical picture of allergic rhinitis, but it is only an indication and certainly not a diagnostic criterion for allergic diseases.