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目的评估重症角结膜干燥症颌下腺移植术后板层角膜移植的临床疗效。设计回顾性病例系列。研究对象15例重症角结膜干燥症颌下腺移植术后患者。方法15例颌下腺移植成功且术后有完整记录患者因角膜病变行板层角膜移植术,术后进行随访观察。主要指标角膜移植片透明性。结果15例行板层角膜移植者2年的随访期间,5例植片保持透明,10例逐渐发生混浊。结论自体颌下腺移植联合角膜移植是治疗重症角结膜干燥症行之有效的方法,但部分病例术后角膜移植失败的原因仍需进一步研究。
Objective To evaluate the clinical efficacy of lamellar keratoplasty after submandibular gland transplantation in patients with severe keratoconus xerophthalmia. Design retrospective case series. Fifteen patients with severe keratoconjunctivitis xenograft underwent submandibular gland transplantation. Methods Fifteen cases of submandibular gland transplantation were performed successfully and there was a complete record after operation. The patients underwent corneal transplantation for corneal disease. Postoperative follow-up was performed. The main indicators of corneal graft transparency. Results During the follow-up of 15 cases with lamellar keratoplasty, 5 cases remained clear and 10 cases gradually developed opacity. Conclusion Autologous submandibular gland transplantation combined with corneal transplantation is an effective method for the treatment of severe keratoconjunctivitis. However, the cause of the failure of corneal transplantation in some cases still needs further study.