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目的分析丙种球蛋白与地塞米松联合治疗病毒性脑炎的临床效果。方法 96例病毒性脑炎患儿,利用双盲、对照法分为试验组和对照组,各48例。对照组接受综合治疗,试验组在对照组基础上加用丙种球蛋白与地塞米松治疗。观察两组相关症状与体征的改善情况,比较临床疗效。结果试验组抽搐、意识障碍、高热、脑膜刺激征及共济失调恢复正常的时间均显著短于对照组,差异具有统计学意义(P<0.05)。试验组显效32例,有效15例,无效1例,总有效率为97.92%;对照组显效23例,有效18例,无效7例,总有效率为85.42%;试验组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。结论病毒性脑炎患儿综合治疗时合理加用丙种球蛋白与地塞米松,可取得更显著的治疗成果。
Objective To analyze the clinical effect of gamma globulin and dexamethasone in the treatment of viral encephalitis. Methods Ninety-six children with viral encephalitis were divided into experimental group and control group by double-blind and control group, with 48 cases in each group. The control group received comprehensive treatment. The experimental group was treated with gamma globulin and dexamethasone on the basis of the control group. The improvement of symptoms and signs of the two groups were observed, and the clinical efficacy was compared. Results The convulsions, disturbance of consciousness, hyperthermia, meningeal irritation and ataxia returned to normal in the experimental group were significantly shorter than those in the control group (P <0.05). In the experimental group, 32 cases were markedly effective, 15 cases were effective and 1 case was ineffective. The total effective rate was 97.92%. In the control group, 23 cases were markedly effective, 18 cases were effective and 7 cases were ineffective. The total effective rate was 85.42% Control group, the difference was statistically significant (P <0.05). Conclusion In the comprehensive treatment of children with viral encephalitis, reasonable addition of gamma globulin and dexamethasone can achieve more significant therapeutic outcomes.