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To systematically evaluate the clinical efficacy and safety of Maren Runchang Pill (麻仁润肠丸) in the treatment of senile constipation. Randomized controlled trials (RCT) on the treatment of senile constipation with Maren Runchang Pill (麻仁润肠丸) were searched by computer in CNKI, CBM, WanFang, VIP, PubMed, EMbase and the Cochrane Library databases. The retrieval time limit was from the establishment of the database to May 2019. A total of 2 researchers independently screened literature and extracted data according to the inclusion criteria, and Meta-analyzed the RCT that met the standards by applying RevMan5.3 software. A total of 5 randomized controlled trials were included, including 395 patients with senile constipation, 199 in the experimental group and 196 in the control group. The treatment group was treated with Maren Runchang Pill (麻仁润肠丸), while the control group was treated with other West medicine, including fruit guide tablets, lactulose oral liquid or kaisailu, etc. The results of Meta-analysis showed that there was no significant difference in the total clinical efficacy between Maren Runchang Pill (麻仁润肠丸) and other West medicines [RR=1.02, 95％CI (0.88, 1.17), P=0.83]. In terms of improvement of abdominal distension and inappetence, there was no significant difference between the treatment with Maren Runchang Pill (麻仁润肠丸) and other West medicine [RR=1.03, 95％CI (0.85, 1.24), P=0.78]. Maren Runchang Pill (麻仁润肠丸). This study showed that the efficacy of Maren Runchang Pill (麻仁润肠丸) in the treatment of senile constipation was not significantly different from that of conventional West medicine, and was safe, and effective, with few adverse reactions. Maren Runchang Pill (麻仁润肠丸), as a traditional Chinese patent medicine, can play the role of regulating qi and replenishing blood, and regulating bowel and bowel laxative, with fewer cost. It is more suitable for the elderly to use, with good compliance, and clinically it should be used with syndrome differentiation. However, due to the quantity and quality of the original study, multi-center, high-quality randomized controlled trials are still needed to further confirm it.