论文部分内容阅读
目的综合介绍微生物持留菌的研究进展,并阐明微生物持留菌的研究对医疗卫生的重要性。方法分别介绍微生物持留菌的定义、特点,指出其重要临床和卫生意义,并综述其形成机制的研究进展,并讨论其将来的研究方向。结果微生物持留菌(persisters)是微生物菌群中极少数没有获得抗药突变但是不会被抗生素杀死的表型变异细胞,若不被免疫系统消灭,在抗生素清除后会重新生长繁殖,造成感染复发,对临床微生物感染的治疗构成极大的威胁。近年来持留菌已成为全球微生物领域、医疗及医药界关注和研究的热点。研究表明影响持留菌形成的机制包括自然形成和外界刺激而成的多种机制,它们在实际上互相交叉,使消灭病原菌持留菌充满挑战。结论持留菌的研究具有重要的医疗卫生意义。持留菌研究发展很快,但各方面研究还不充分,动物模型和临床研究尤为欠缺。持留菌在生态学方面的研究,以及益生菌持留菌的应用研究则尚待开展。
Objective To summarize the progress of research on microbial retention bacteria and to elucidate the importance of the research on microbial retention bacteria in medical and health care. Methods The definition, characteristics of microorganism retaining bacteria were introduced respectively, and its important clinical and hygienic significance were pointed out. The research progress of its formation mechanism was reviewed and its future research directions were discussed. Results Microbial persisters are phenotypically variant cells in the microflora that do not have drug-resistant mutations but are not killed by antibiotics. If not eliminated by the immune system, the persisters will re-grow and become infected after antibiotic clearance Recurrence, the treatment of clinical microbial infections constitute a great threat. In recent years, bacteriocin has become a hot spot in the world of microorganisms, medical and pharmaceutical industries. Studies show that the mechanisms that influence the formation of bacteriostasis include multiple mechanisms of natural formation and external stimuli that actually cross each other and challenge the elimination of pathogenic bacteria. Conclusion The study of bacteriostasis has important medical and health significance. Bacteriostasis research has developed rapidly, but all aspects of research are not sufficient animal models and clinical studies are particularly scarce. Holistic bacteria in the ecological aspects of research, as well as the use of probiotic bacteria remain to be carried out.