目的探讨结肠、直肠癌活检病理的诊断。方法结肠、直肠癌活检病理标本的石蜡切片175例,对所有石蜡切片进行阅片诊断。结果 173例患者在手术后康复,2例患者死亡;且有104例(59.43%)患者的癌侵及黏膜下层浸润情况难以判断,在术后病理诊断中归为了浸润癌。结论临床上准确诊断结肠、直肠癌活检病理,能够有效提高患者的治愈率。 Objective To investigate the biopsy diagnosis of colon and rectal cancer. Methods 175 paraffin sections of biopsy specimens of colon and rectal cancer were biopsy. Results 173 patients recovered after surgery and 2 patients died. In 104 patients (59.43%), the invasion of carcinoma and submucosal invasion were difficult to judge. The pathological diagnosis was classified as invasive carcinoma. Conclusion Clinically accurate diagnosis of colorectal cancer biopsy pathology, can effectively improve the cure rate of patients.