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目的 研究胃癌术后早期腹腔持续温热灌注化疗的安全性。方法 1998-2001年共收治胃癌患者848例,随机分为胃癌术后早期腹腔持续温热灌注化疗组与对照组,其中治疗组304例,对照组544例。对比两组之间在术后水电解质平衡、出血、吻合口瘘、十二指肠残端瘘、伤口愈合、化疗药物毒副反应、术后肠粘连或肠梗阻等并发症方面的差异。结果 术后早期腹腔持续温热灌注化疗组与对照组在并发症上无显著性差异。结论 胃癌术后早期腹腔持续温热灌注化疗是安全的。
Objective To study the safety of early peritoneal hyperthermic perfusion chemotherapy of gastric cancer after operation. Methods A total of 848 gastric cancer patients were admitted to our hospital from 1998 to 2001 and were randomly divided into continuous intraperitoneal hyperthermic perfusion chemotherapy group and control group after operation, of which 304 were treated group and 544 were control group. The differences between the two groups in the complication of water-electrolyte balance, bleeding, anastomotic fistula, duodenal stump fistula, wound healing, toxic side effects of chemotherapy drugs, postoperative intestinal adhesion or intestinal obstruction were compared. Results There was no significant difference in the postoperative complications between the early postoperative peritoneal warm infusion chemotherapy group and the control group. Conclusions Early peritoneal hyperthermic perfusion chemotherapy of gastric cancer is safe.