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目的探索盐酸羟考酮缓释片在晚期肿瘤中重度疼痛患者中的止痛效果。方法回顾性分析于2014年3月~2017年3月收治的40例晚期肿瘤中重度疼痛患者,所有患者均采用盐酸羟考酮缓释片进行治疗,治疗前对患者的疼痛进行全面评估,根据患者的疼痛评分选择合适的初始剂量,并根据患者每天出现爆发痛的情况进行适当的剂量调整,对患者治疗前后的生活质量及爆发痛的次数进行观察分析。结果 40例患者最终盐酸羟考酮缓释片的每天剂量为40~240 mg,治疗后疼痛控制达到满意者为31例,控制满意度为77.5%,治疗后患者出现爆发痛的情况明显减少。结论盐酸羟考酮缓释片具有较好的镇痛作用,对于晚期肿瘤中重度疼痛疗效较好,治疗后副作用较低,可供晚期肿瘤患者长期应用。
Objective To investigate the analgesic effect of oxycodone hydrochloride sustained-release tablets in patients with severe pain in advanced tumors. Methods A retrospective analysis was performed on 40 patients with moderate-to-severe pain who were admitted to our hospital from March 2014 to March 2017. All patients were treated with oxycodone hydrochloride sustained-release tablets. Patients’ pain was evaluated before treatment. According to Patient’s pain score Select the appropriate initial dose, and according to the daily occurrence of explosive pain in patients with appropriate dose adjustment, the quality of life before and after treatment and the number of patients with pain were observed and analyzed. Results The final dose of oxycodone hydrochloride sustained-release tablets in 40 patients was 40 ~ 240 mg per day after treatment, 31 patients achieved satisfactory pain control after treatment, and the control satisfaction was 77.5%. The incidence of explosive pain was significantly reduced after treatment. Conclusion Oxycodone hydrochloride sustained-release tablets have good analgesic effect, good effect on severe pain in advanced stage tumors and low side-effect after treatment, which can be used for long-term treatment of patients with advanced stage tumors.