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目的观察不同化疗方案治疗恶性滋养细胞肿瘤的的临床效果。方法恶性滋养细胞肿瘤患者60例,随机分为A、B组各30例。B组采用5-FU单药化疗,A组采用卡铂、氨甲蝶呤、长春新碱联合化疗。结果两组均治疗3个疗程。B组5例因耐受问题转手术治疗;A组1例转手术根治切除。A组30例有效28例,无效2例,有效率为93.3%;B组分别为23、7例和76.7%,两组有效率相比,P<0.05。B组出现骨髓抑制2例,胃肠道反应和脱发各1例;A组分别为2、2、1例,均经对症处理后出院。两组不良反应情况相比,P均>0.05。结论卡铂、氨甲蝶呤、长春新碱联合化疗治疗恶性滋养细胞肿瘤疗效可靠,不良反应较小。
Objective To observe the clinical effects of different chemotherapy regimens in the treatment of malignant trophoblastic tumors. Methods Sixty patients with malignant trophoblastic tumor were randomly divided into A and B groups of 30 cases. Group B received 5-FU monotherapy, and group A received carboplatin, methotrexate, and vincristine in combination with chemotherapy. Results Both groups were treated for 3 courses. In group B, 5 patients underwent surgery because of tolerance; in group A, 1 patient underwent radical resection. A group of 30 cases effective in 28 cases, 2 cases were ineffective, the effective rate was 93.3%; B group were 23,7 cases and 76.7%, respectively, the effective rate of the two groups compared, P <0.05. B group appeared bone marrow suppression in 2 cases, gastrointestinal reactions and hair loss in 1 case; A group were 2, 2, 1, were discharged after symptomatic treatment. Adverse reactions between the two groups, P> 0.05. Conclusion Carboplatin, methotrexate, vincristine and chemotherapy in the treatment of malignant trophoblastic tumor are reliable and the adverse reaction is small.