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新型抗癫痫药物噻嗪磺胺（I）国外商品名:Sulthiame,Sultiam,Ospolot;化学名:N—（4—磺酰胺基苯基）—1,4—丁磺内酰胺。〔《医药工业》编辑部建议该药暂定名为噻嗪磺胺,国内译名还有欧斯旁特（Ospolot）和苏太明（Sultiam）〕。 本品由德国拜尔（Bayer）公司创制。具有低毒、高效、无催眠性等特点,用于治疗癫痫大发作、肌挛性发作、病灶性癫痫等。我们于1981年报道了此药的实验室合成,所采用的路线如下:
The new antiepileptic drugs Thiazide Sulfonamide (I) Foreign Trade Name: Sulthiame, Sultiam, Ospolot; chemical name: N- (4-sulfonamidophenyl) -1,4-butane sultam. The editorial department of the Pharmaceutical Industry proposed that the drug be tentatively named thiazide sulfonamides, and the domestic names are Ospolot and Sultiam. This product by the German Bayer (Bayer) company created. With low toxicity, high efficiency, no hypnosis and other characteristics for the treatment of epilepsy seizure, myoclonic seizures, focal epilepsy and so on. We reported the laboratory synthesis of this drug in 1981 using the following route: