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目的:观察“女贞子-枸杞子”对去卵巢骨质疏松症大鼠血清中IL-10、IL-17水平的影响,探讨补阴药防治绝经后骨质疏松症的作用机制。方法:3月龄SD雌性大鼠60只,分为假手术组、模型组、阳性对照组、壮骨止痛胶囊组、女贞子-枸杞子组,对除假手术组外的其余组大鼠去卵巢3个月,制备绝经后骨质疏松症病理模型,手术后1周灌胃给药,连续13周。检测比较各组大鼠血清IL-10、IL-17水平。结果:与模型组比较,壮骨止痛胶囊组、女贞子-枸杞子组血清IL-10水平均明显升高,差异有统计学意义(P<0.05);各给药组IL-17水平均有明显降低趋势,但与模型组差异无统计学意义(P>0.05)。结论:女贞子-枸杞子能明显升高骨质疏松模型雌鼠血清IL-10水平,且能小幅度提高其IL-17水平,从而达到抗绝经后骨质疏松的目的。
Objective: To observe the effect of “Ligustrum lucidum - Lycium barbarum” on serum levels of IL-10 and IL-17 in ovariectomized rats with osteoporosis and to explore the mechanism of the Yin-controlling drugs in preventing and treating postmenopausal osteoporosis. Methods: Sixty SD female rats of 3 months old were divided into sham-operation group, model group, positive control group, Zhuanggu Zhitong Capsule group and Fructus Ligustri Lucidi-Fructus group, Ovaries were ovariectomized for 3 months to prepare the pathological model of postmenopausal osteoporosis. Gavage administration was given for 1 week after surgery for 13 weeks. The levels of IL-10 and IL-17 in serum of rats in each group were detected and compared. Results: Compared with model group, serum IL-10 levels of Zhuoguzhitong Capsule group and Fructus Ligustri Lucidi-Fructus Fructus group were significantly increased (P <0.05). The levels of IL-17 in each group There was a significant decrease tendency, but there was no significant difference with the model group (P> 0.05). Conclusion: Ligustrum lucidum and Fructus Lycii can significantly increase the level of serum IL-10 in osteoporosis model female mice, and can increase its level of IL-17 slightly to achieve anti-postmenopausal osteoporosis.