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用胶体载体包埋化学治疗剂具有包埋剂量大而且相对较易制备的优点,其中微球运载系统特别具有优势。粒度范围在1～32μm 的白蛋白做球是用水包油乳化方法包括化学稳定和加热法制备的。给药途径、颗粒大小和颗粒表面特性能改变微球在体内的定位和分布。颗粒大小和粒度分布对药物的释放有着重要的影响。用激光衍射方法进行颗粒大小分析,根据SPAN 变最来衡量粒度分布(即多散性):SPAN=(D_(90%)-D_(10%))/(D_(50%))上式中D_(90%),D_(10%),D_(50%)指颗粒的直径,SPAN 数值高表示粒度分布广和分散性高。
Embedding chemotherapeutic agents with colloidal carriers has the advantage of being embeddable in large quantities and relatively easy to prepare, with microsphere delivery systems having particular advantages. Albumin balls ranging in size from 1 to 32 μm are prepared by oil-in-water emulsions including chemical stabilization and heating. The route of administration, particle size and particle surface characteristics can alter the localization and distribution of the microspheres in the body. Particle size and particle size distribution of the drug has an important impact on the release. Particle size analysis was performed by laser diffraction method, and the particle size distribution (ie, polydispersity) was measured according to the SPAN: SPAN = D 90% - D 10% / D 50% D_ (90%), D_ (10%), D_ (50%) refers to the particle diameter, SPAN high value indicates that the particle size distribution and dispersion of high.