目的:评估早期静脉溶栓联合抗凝治疗急性心肌梗死(AM I)的效果。方法:对80例发病至治疗时间≤6h的患者进行尿激酶联合低分子肝素钙抗凝治疗,并对其疗效进行分析。结果:发病≤4 h以内接受治疗61例,血管再通者50例,占81.9%。发病4 h~6 h以内接受治疗19例,血管再通者14例,占73.7%。80例中6 h内再通者64例,占总例数80%。结论:早期静脉溶栓联合抗凝,治疗AM I,其越早应用效果越佳,血管再通率达81.9%,广大基层医院在无心脏介放及冠状动脉搭桥术的条件下,只要认真选择好适应证,并仔细观察临床变化认真分析对照心电图、心肌酶谱变化,适时针对性预防和治疗并发症,基层医院也能及时抢救治疗急性心肌梗死患者,同时也减少了患者的治疗费用。可为广大低收入患者所能接受的较好的治疗方法。 Objective: To evaluate the effect of early intravenous thrombolysis combined with anticoagulation in the treatment of acute myocardial infarction (AMI). Methods: 80 patients with onset to treatment time ≤ 6h were treated with urokinase combined with low molecular weight heparin anticoagulant therapy, and its efficacy was analyzed. Results: 61 cases were treated less than 4 hours and 50 cases were recanalized, accounting for 81.9%. The incidence of 4 h ~ 6 h within 19 cases of treatment, recanalization in 14 cases, accounting for 73.7%. In 80 cases, 64 cases recanalized within 6 hours, accounting for 80% of the total cases. Conclusion: The early intravenous thrombolysis combined with anticoagulation, the treatment of AM I, the sooner the application of the better, the rate of recanalization reached 81.9%, the majority of primary hospitals in the absence of cardiac intervention and coronary artery bypass grafting conditions, as long as careful selection Good indications, and carefully observe the clinical changes carefully analyze the control ECG, changes in myocardial enzymes, timely targeted prevention and treatment of complications, grass-roots hospitals can promptly rescue patients with acute myocardial infarction, but also reduce the cost of treatment of patients. For the majority of low-income patients can accept a better treatment.