对22例用综合疗法治疗的重型病毒性肝炎(重肝)患者进行了血液流变学观察,18例病人还检测了血浆血栓素B_2(TXB_2)和内毒素。治疗前病人全血比粘度(高切)、全血还原比粘度(高切、低切)及血浆TXB_2均升高;治疗期间均降低。18例病人中有13例发生了内毒素血症(ETM)。提示本疗法对改善重肝病人的血液流变学异常,疏通微循环似有一定作用;TXB_2、ETM和血液流变学异常与重肝时微循环障碍可能有一定关系。 Hemorheology was observed in 22 patients with severe viral hepatitis (severe liver) treated with combination therapy, and 18 patients were also tested for plasma thromboxane B 2 (TXB 2) and endotoxin. Before treatment, the whole blood specific viscosity (high cut), whole blood reduction specific viscosity (high and low cut) and plasma TXB_2 increased; both were decreased during treatment. Thirteen of the 18 patients developed endotoxemia (ETM). These results suggest that this therapy may play an important role in improving hemorheology abnormalities and clearing microcirculation in patients with severe hepatitis. The abnormalities of TXB_2, ETM and hemorheology may be related to microcirculation disturbance in severe liver.