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在SiO_2刺激下,肺的防御和免疫功能获得加强,这是对机体有积极意义的一面。但据文献报告,肺泡巨噬细胞吞噬SiO_2后能导致其溶酶体膜和细胞膜损害以及肺泡巨噬细胞自身的崩解,随之加速纤维化的形成,故肺泡巨噬细胞数目和吞噬SiO_2量的增加,又成为对机体有害的一面。为了探索维生素E对染尘后大鼠肺泡巨噬细胞吞噬功能的影响,借以了解维生素E对抗实验性矽肺形成的机制的某些环节,我们做了以下实验:
Under the stimulation of SiO_2, lung defense and immune function are strengthened, which is a positive aspect to the body. However, it has been reported in the literature that the phagocytosis of SiO 2 by alveolar macrophages results in the damage of lysosomal membranes and cell membranes and the disintegration of alveolar macrophages themselves, which in turn accelerates the formation of fibrosis. Therefore, the number of alveolar macrophages and phagocytosis of SiO 2 Increase, but also become harmful to the body side. In order to explore the effect of vitamin E on the phagocytosis of alveolar macrophages in post-dyed rats and to understand some aspects of the mechanism of vitamin E against experimental silicosis, we did the following experiments: