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目的 :研究贵州省黔西县少数民族 β 地中海贫血的发病率和杂合子的血液学状态 ,为提高人口素质服务。方法 :用血液学方法对贵州省黔西县 6个少数民族共 1 2 2 3名当地常住居民进行 β 地中海贫血筛查。 结果 :从 1 2 2 3名少数民族中共检出 β 地中海贫血携带者 4 4例 ,检出率 3 6 %。其中 ,以布依族检出率最高 ,为7 4 %。其余依次是满族、白族、苗族、仡佬族及彝族。同时在检出的 4 4例阳性标本中发现 7例疑属HbE/ β 地中海贫血 ,满族 6例 ,彝族 1例。结论 :贵州省黔西县 6个少数民族为 β 地中海贫血的高发人群 ,而且具有显著的民族特征 ,是我国一个较为特殊的 β珠蛋白生成障碍性贫血分布区域
OBJECTIVE: To study the incidence of β-thalassemia and the hematological status of heterozygotes for ethnic minorities in Qianxi County, Guizhou Province, in order to improve the population quality. Methods: The β-thalassemia screening was performed by using hematology method on 1223 local residents from 6 ethnic minorities in Qianxi County, Guizhou Province. Results: Forty-four cases of β-thalassemia carriers were detected from 1222 minority nationalities, the detection rate was 36%. Among them, the highest detection rate is Buyi, 74%. The rest followed by Manchu, Bai, Miao, Mulam and Yi. At the same time, 7 cases of suspected HbE / β thalassemia were found in 4 4 positive samples, including 6 cases of Manchu and 1 case of Yi. CONCLUSION: Six ethnic minorities in Qianxi County of Guizhou Province are high prevalence of β-thalassemia and have significant ethnic characteristics, which is a special distribution area of β-thalassemia in China