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Long等首先报道有胆碱样结构的双季铵盐,双[4-(二甲基β-羟乙铵基)苯乙酮二溴化合物(Ⅰ),它在溶液中迅速经分子内环化产生具有强烈生理活性的半缩醛(Ⅱ)Hemicholinium-3(简称HC-3)。
Long et al. First reported that the choline quaternary ammonium salt, bis [4- (dimethyl beta-hydroxyethylammonio) acetophenone dibromo compound (I), which is rapidly cyclized intramolecularly in solution Hemicholinium-3 (HC-3) is produced with a strong physiological activity.