文章概述了胎儿期唇腭裂的发生、相关因素、诊断和治疗。介绍了胎儿唇腭裂与染色体异常发生率的关系。随着产前诊断技术(超声、MR I等)的提高,越来越多的胎儿唇腭裂得到诊断。胎儿镜等技术促进了胎儿宫内治疗的发展,唇腭裂的宫内治疗亦是一个趋势,但目前大量的研究仍然是局限在动物模型。 The article outlines the occurrence of fetal cleft lip and palate, related factors, diagnosis and treatment. The relationship between fetal cleft lip and palate and the incidence of chromosomal abnormalities was introduced. With the prenatal diagnosis techniques (ultrasound, MRI, etc.) increased, more and more fetus cleft lip and palate was diagnosed. Fetal mirror technology to promote the development of intrauterine fetal treatment, cleft lip and palate intrauterine therapy is also a trend, but a large number of studies are still limited to animal models.