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目的探讨过氧化损伤与妊高征早期肾功能损害的关系。方法对2008年1月~8月入住我院260例妊高征孕妇,进行血清中的超过氧化物歧化酶(SOD)检测,并将其与尿微量白蛋白(MAL)、β2-微球蛋白(β2-m)、24h总蛋白(TP)的相互关系进行分析。结果重度子痫前期组患者中,其SOD水平及尿MAL、β2-m、24h尿蛋白定量与妊娠对照组比较差异显著(P<0.01),有统计学意义;轻度子痫前期组与妊娠对照组比较,血清SOD阳性率为76.13%,尿MAL、β2-m、24h蛋白定量阳性率分别65.91%、28.41%、47.73%;妊娠高血压组尿MAL、β2-m、24h尿蛋白定量与对照组无明显差异(P>0.05),尿MAL、β2-m、24h尿蛋白定量阳性率分别15.70%、6.61%,12.40%,而血清SOD阳性率42.98%,与对照组相比也有统计学意义。结论检测血清SOD水平对妊高征患者早期肾脏功能损害有诊断价值。
Objective To investigate the relationship between early oxidative damage and early renal dysfunction induced by pregnancy induced hypertension. Methods A total of 260 PIH pregnant women admitted to our hospital from January 2008 to August 2008 were enrolled in this study. Serum levels of superoxide dismutase (SOD) were measured and compared with urinary microalbumin (MAL), β2-microglobulin (β2-m), 24h total protein (TP) were analyzed. Results In the severe preeclampsia group, the level of SOD and the urinary protein excretion of MAL, β2-m and 24-h were significantly different from those of the pregnant control group (P <0.01), and the difference was statistically significant. In mild preeclampsia group and pregnancy The positive rates of serum MAL, β2-m and 24h were 65.91%, 28.41% and 47.73% respectively in the control group. The positive rate of serum MAL, β2-m and 24h urinary protein in pregnancy-induced hypertension group was 76.13% The positive rate of urine MAL, β2-m and 24h urinary protein were 15.70%, 6.61% and 12.40%, respectively, while the positive rate of serum SOD was 42.98%, which was also statistically significant compared with the control group significance. Conclusion Detecting serum SOD level has diagnostic value for early renal dysfunction in patients with PIH.