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目的探讨TSH阳性切值降低对新生儿疾病筛查是否有影响。方法降低卫生部TSH阳性切值对2011-2012年收到共460 295例广西地区新生儿干血片进行疾病筛查。结果按卫生部规定的TSH阳性切值10μIU/ml,筛查出可疑阳性2727例(其中被召回2315例),确诊甲低210例,高TSH血症238例;经统计将TSH阳性切值降为8μIU/ml后筛查出可疑阳性5799例,增加3072例(其中被召回4878例,新增召回2563例),确诊甲低229例(新增19例甲低),高TSH血症300例(新增62例高TSH血症)。结论在提高干血片质量和实验室质控在控减少假阳性前提下,降低TSH阳性切值对广西地区新生儿疾病筛查产生重要影响。
Objective To investigate if the reduction of TSH positive cut value has an impact on the screening of neonatal diseases. Methods To reduce the TSH positive cut-off value of the Ministry of Health for disease screening of 460 295 newborn blood transfusions received from 2011 to 2012 in Guangxi. Results According to the TSH positive cut-off value of 10μIU / ml prescribed by the Ministry of Health, 2727 suspicious positives (of which 2315 were recalled) were screened, 210 cases were diagnosed as hypothyroidism and 238 cases were hypercholesteremia. According to the statistics, After 8μIU / ml screened positive suspicious 5799 cases, an increase of 3072 cases (of which 4878 were recalled, the new recalled 2563 cases), a hypothyroidism in 229 cases (19 cases of hypothyroidism), 300 cases of hyperhreraemia (62 new high TSH hyperlipidemia). Conclusion In improving the quality of dry blood chip and laboratory quality control in reducing the false positive under the premise of reducing the TSH-positive cut value on Guangxi neonatal screening have a significant impact.