目的评估空腹血清甘胆酸（ＣＧ）测定对肝硬变患者的临床意义．方法肝硬变患者１０２例，采用放免法测定空腹血清甘胆酸水平．按Ｃｈｉｌｄ分级法将上述患者分为Ａ（２１例），Ｂ（３１例）和Ｃ（５０例）三级．结果本组１０２例患者中有９６０％（９８例）血清ＣＧ水平高于正常，其中ＣｈｉｌｄＡ级为９０５％，Ｂ和Ｃ级分别为９３５％和１００％．肝硬变Ｂ级（４４１μｍｏｌ／Ｌ±２８６μｍｏｌ／Ｌ）和Ｃ级（４４６μｍｏｌ／Ｌ±３３３μｍｏｌ／Ｌ）的ＣＧ水平明显高于Ａ级（１９５μｍｏｌ／Ｌ±１１６μｍｏｌ／Ｌ，Ｐ＜００１），但Ｂ，Ｃ两组间无差异（Ｐ＞０１）．血清ＣＧ水平与血清总胆红素之间呈正相关，而与血清白蛋白呈负相关．结论空腹血清ＣＧ测定有助于评估肝硬变的严重程度及预后． Objective To evaluate the clinical significance of fasting serum glycocholic acid (CG) in cirrhotic patients. Methods 102 patients with cirrhosis were tested for fasting serum glycocholic acid by radioimmunoassay. The patients were divided into A (21 cases), B (31 cases) and C (50 cases) according to Child classification. Results The serum CG level of 96.0% (98 cases) was higher than normal in 102 patients. The ChildA level was 90.5% and the B and C levels were 93.5% and 100% respectively. The levels of CG in liver cirrhosis with grade B (441μmol / L ± 286μmol / L) and grade C (446μmol / L ± 333μmol / L) were significantly higher than those with grade A (195μmol / L ± 11  6μmol / L, P <001), but there was no difference between B and C (P> 01). Serum CG levels were positively correlated with serum total bilirubin but negatively correlated with serum albumin. Conclusion Fasting serum CG can be helpful in assessing the severity and prognosis of cirrhosis.