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老年多器官功能衰竭(MOFE)是新提出的临床综合征,其发病机理尚待深入研究。本文研究发现MOFE时血浆过敏毒素(C5a)活性,血清中分子量物质(MSS)、丙二醛(MDA)的浓度,超氧化物岐化酶(SOD)活力较健康老年人明显升高;而血清纤维连接蛋白(Fn)及支链氨基酸/芳香族氨基酸比值(BCAA/AAA)较健康老年人明显降低,提示C5a和Fn与MOFE的发生有关。对象与方法一、检查对象健康老年人32例,男26例,女6例,年龄65～80岁,MOFE25例,男23例,女2例,年
Senile multiple organ failure (MOFE) is a newly proposed clinical syndrome, its pathogenesis remains to be further studied. In this study, we found that the activities of C5a, MSS, MDA and SOD in MOFE were significantly higher than those in healthy elders. However, serum levels of The ratio of fibronectin (Fn) and branched chain amino acids / aromatic amino acids (BCAA / AAA) was significantly lower than that in healthy elders, suggesting that C5a and Fn were associated with the occurrence of MOFE. Subjects and methods First, the object of examination Healthy elderly 32 cases, 26 males and 6 females, aged 65 to 80 years, MOFE25 cases, 23 males and 2 females, year