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目的:探讨血清可溶性细胞间黏附分子-1(sICAM-1)与2型糖尿病肾病的关系。方法:酶联免疫吸附法(ELISA)测定60例2型糖尿病患者和20例正常人血清sICAM-1含量,检测尿白蛋白排泄率(UAER)、肌酐(Cr)、总胆固醇(TC)、甘油三脂(TG)等指标。比较不同UAER患者sICAM-1及血糖、血脂指标的差异,并分析2型糖尿病患者sICAM-1与UAER及血脂的关系。结果:糖尿病患者血清sICAM-1水平比正常对照组明显升高,其浓度随病程的延长和尿白蛋白排泄率的增加而显著增高(P<0.05),sICAM-1与UAER、TC、TG呈显著正相关(P<0.05)。结论:糖尿病肾病血清sICAM-1水平升高与尿白蛋白排泄率关系密切,sICAM-1有望作为判断糖尿病肾病肾损害程度的指标之一。
Objective: To investigate the relationship between serum soluble intercellular adhesion molecule-1 (sICAM-1) and type 2 diabetic nephropathy. Methods: Serum sICAM-1 levels were measured in 60 patients with type 2 diabetes mellitus and 20 normal persons by enzyme-linked immunosorbent assay (ELISA), urinary albumin excretion rate (UAER), creatinine (Cr), total cholesterol Three fat (TG) and other indicators. The differences of sICAM-1, blood glucose and blood lipid in patients with UAER were compared. The relationship between sICAM-1 and UAER and blood lipid in type 2 diabetic patients was also analyzed. Results: Serum sICAM-1 levels in diabetic patients were significantly higher than those in normal controls (P <0.05). The concentrations of sICAM-1, UAER, TC and TG in patients with diabetes mellitus were significantly increased Significant positive correlation (P <0.05). Conclusion: The serum sICAM-1 level in diabetic nephropathy is closely related to the urinary albumin excretion rate. SICAM-1 is expected to be used as one of the indicators to judge the degree of renal damage in diabetic nephropathy.