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目的通过对3358例急性肾绞痛患者的回顾性分析,对常用的几种缓解疼痛的方法进行比较,探寻治疗重度肾绞痛的最佳方案。方法确诊重度肾绞痛患者3358例随机分组,采用以下止痛方法:解痉药+M受体阻滞药;弱阿片类药+M受体阻滞药;非甾体类抗炎药+M受体阻滞药;强阿片类药物。评价给药30 min内疼痛缓解的效果并进行分析。结果解痉药+M受体阻滞药组总有效率92%,弱阿片类药+M受体阻滞剂组总有效率73%,非甾体类抗炎药+M受体组总有效率95%,强阿片类药物组总有效率96.2%。非甾体类抗炎药+M受体组疗效优于解痉药+M受体阻滞药组和弱阿片类药+M受体阻滞剂组(P<0.05),不良反应发生情况优于强阿片类药物组。结论非甾体类抗炎药+M受体阻滞药可代替强阿片类药物治疗重度肾绞痛。
Objective By retrospective analysis of 3358 patients with acute renal colic, several commonly used methods of pain relief were compared to explore the best treatment for severe renal colic. Methods 3358 patients diagnosed with severe renal colic were randomly assigned to the following analgesic methods: antispasmodic drug + M blocker; weak opioid + M blocker; NSAID + M receptor Blocking drugs; strong opioids. The effect of pain relief within 30 min after administration was evaluated and analyzed. Results The total effective rate was 92% in antispasmodic drug + M receptor antagonist group, 73% in weak opioid + M receptor antagonist group, and non-steroidal anti-inflammatory drug + M receptor group was 95% efficiency, strong opioid group, the total efficiency of 96.2%. The efficacy of NSAIDs + M receptor group was better than that of antispasmodics + M receptor blockers and weak opioids + M receptor blockers (P <0.05), and the incidence of adverse reactions was superior Yu Qiang opioid group. Conclusion Non-steroidal anti-inflammatory drugs + M blockers can replace strong opioids in the treatment of severe renal colic.