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目的 为探讨我国胃癌高发区农村成年居民血清胃蛋白酶原Ⅰ (PepsinogenⅠ ,PGⅠ )、胃蛋白酶原Ⅱ (PGⅡ )和胃泌素 (Gastrin ,GAS)水平和分布规律。方法 以放射免疫学方法对赞皇县 15 0 4名 30岁以上居民血清PGⅠ、PGⅡ和GAS水平进行了定量分析。结果 赞皇县居民血清PGⅠ、PGⅡ、PGⅠ /PGⅡ比值和GAS值变异范围非常大 ,明显偏离正态分布 ,其中位值分别为 5 6 30 μg/L、12 5 0 μg/L、4 6和 72 0 0pg/ml。男性居民血清PGⅠ、PGⅡ、PGⅠ /PGⅡ比值 (6 4 90 μg/L、13 80 μg/L、4 85 )均明显高于女性居民 (49 95 μg/L、11 5 5 μg/L、4 4 0 ;P均 <0 0 0 0 1) ,而男女居民血清GAS水平无明显差异。不同年龄组居民血清PGⅠ、PGⅡ水平有一定差异 ,但PGⅠ /PGⅡ比值差异不明显。结论 赞皇县农村成年居民血清PGⅠ、PGⅡ、PGⅠ /PGⅡ和GAS值明显偏离正态分布。血清PG水平有显著性别差异。
Objective To investigate the levels and distribution of serum pepsinogen Ⅰ (PGⅠ), pepsinogen Ⅱ (PGⅡ) and gastrin (GAS) in rural residents with high incidence of gastric cancer in our country. Methods Radioimmunoassay was used to quantitatively analyze the serum levels of PGⅠ, PGⅡ and GAS in 1504 residents over the age of 30 in Zanhuang County. Results The range of PGⅠ, PGⅡ, PGⅠ / PGⅡ and GAS in Zanghuang residents was very wide and significantly deviated from the normal distribution, with median values of 56 30 μg / L, 125 000 μg / L, 46 and 72 0 0 pg / ml. The serum PGⅠ, PGⅡ and PGⅠ / PGⅡ ratios (6 4 90 μg / L, 13 80 μg / L, 4 85) of male residents were significantly higher than those of female residents (49 95 μg / L, 11 5 5 μg / L, 4 4 0; P <0 0 0 0 1), while there was no significant difference between men and women in serum GAS level. The serum levels of PGⅠ and PGⅡ in residents of different age groups were different, but the PGⅠ / PGⅡ ratio was not significantly different. Conclusion The serum PGⅠ, PGⅡ, PGⅠ / PGⅡ and GAS values of adult residents in rural areas of Zanhuang County deviate significantly from the normal distribution. Serum PG levels have significant gender differences.