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目的:观察康妇炎胶囊联合盐酸左氧氟沙星分散片治疗慢性盆腔炎的临床疗效及对患者血流变学、炎性因子的影响。方法:将慢性盆腔炎患者200例随机分成2组各100例,对照组口服盐酸左氧氟沙星分散片;治疗组在对照组治疗基础上加服康妇炎胶囊;观察2组临床疗效以及治疗前后患者血流变学、细胞因子的变化。结果:总有效率治疗组为87.0%,对照组为77.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血浆浓度和全血黏度(低切,高切)均较治疗前降低(P<0.05);且治疗组上述各指标均低于对照组(P<0.05)。治疗后,2组白细胞介素-2、肿瘤坏死因子-α较治疗前降低(P<0.05),白细胞介素-10较治疗前升高(P<0.05);且治疗组上述指标改善较对照组更显著(P<0.05)。结论:康妇炎胶囊联合盐酸左氧氟沙星分散片对慢性盆腔炎的治疗效果优于单纯西药治疗。
Objective: To observe the clinical efficacy of Kang Fu Yan capsules combined with levofloxacin hydrochloride dispersible tablets in the treatment of chronic pelvic inflammatory disease and its effect on hemorheology and inflammatory factors. Methods: 200 cases of patients with chronic pelvic inflammatory disease were randomly divided into 2 groups of 100 cases, the control group oral levofloxacin tablets; treatment group in the control group based on the treatment of Kang Fu Yan capsule; observed two groups of patients with clinical efficacy and before and after treatment of blood Rheology, changes in cytokines. Results: The total effective rate was 87.0% in the treatment group and 77.0% in the control group. There was significant difference between the two groups (P <0.05). After treatment, plasma concentration and whole blood viscosity (low cut and high cut) in both groups were lower than those before treatment (P <0.05). The above indexes in the treatment group were lower than those in the control group (P <0.05). After treatment, the levels of interleukin-2 and tumor necrosis factor-α in the two groups were lower than those before treatment (P <0.05), while the levels of interleukin-10 were higher than those before treatment (P <0.05) Group was more significant (P <0.05). Conclusion: Kang Fu Yan capsules combined with levofloxacin hydrochloride dispersible tablets in the treatment of chronic pelvic inflammatory disease is superior to Western medicine alone.