目的:探讨医院内真菌性败血症的临床特点与治疗方法。方法:对107例医院内真菌性败血症的临床资料进行回顾性分析。结果和结论:107例中,以严重基础疾病(100%),使用广谱抗生素(97%)为主要易感因素。重症外科组中各种侵入性插管(93%),普通内科组中应用肾上腺皮质激素、免疫抑制药(分别为36%、21%),恶性血液病组与肿瘤组中应用化学治疗、中性粒细胞减少等也为重要易感因素。主要致病菌为白假丝酵母菌与热带假丝酵母菌,氟康唑、两性霉素B加氟胞嘧啶为抗真菌的有效药物。尽量避免及改善易感因素,尽早明确诊断与治疗有助于改善预后。 Objective: To investigate the clinical characteristics and treatment of fungal septicemia in hospital. Methods: The clinical data of fungal septicemia in 107 hospitals were retrospectively analyzed. RESULTS AND CONCLUSION: Among 107 cases, the most common underlying diseases (100%) and the broad-spectrum antibiotics (97%) were the major predisposing factors. Severe surgical group in a variety of invasive intubation (93%), the general internal medicine group with adrenal cortex hormones, immunosuppressive drugs (36%, respectively, 21%), hematological malignancy group and the chemotherapy group, Neutropenia is also an important predisposing factor. The main pathogens are Candida albicans and Candida tropicalis, fluconazole, amphotericin B plus flucytosine effective antifungal drugs. Try to avoid and improve the susceptibility factors, as soon as possible to confirm the diagnosis and treatment can help improve the prognosis.