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目的:比较中药汤剂联合静脉化疗方案和单独使用静脉化疗方案对结直肠癌患者细胞免疫功能的影响。方法:检索2010年1月—2015年10月有关比较中药汤剂联合静脉化疗方案和单独使用静脉化疗方案对结直肠癌患者细胞免疫功能影响的随机对照研究的中英文文献。评价纳入文献质量,并进行Meta分析。结果:经严格筛选,最终纳入21篇随机对照文献,涉及1267例患者,其中中药汤剂联合静脉化疗方案组638例,单独使用静脉化疗方案组629例。Meta分析结果显示:与单独使用静脉化疗方案相比,中药汤剂联合静脉化疗方案在改善CD3_~+、CD4_~+、NK、CD4_~+/CD8_~+比值方面有统计学意义,在改善CD8_~+方面无统计学意义。结论:中药汤剂联合静脉化疗方案可以改善结直肠癌患者的细胞免疫功能,但还需要大量的多中心随机对照临床试验加以证实。
Objective: To compare the effects of traditional Chinese medicine decoction combined with intravenous chemotherapy and intravenous chemotherapy alone on cellular immune function in patients with colorectal cancer. METHODS: The articles in Chinese and English from January 2010 to October 2015 were searched for a randomized controlled study comparing the effects of Chinese herbal decoction with intravenous chemotherapy and intravenous chemotherapy alone on cellular immune function in patients with colorectal cancer. The evaluation included the quality of the literature and conducted a meta-analysis. Results: After rigorous screening, 21 randomized controlled trials were finally included, involving 1267 patients, of which 638 were treated with Chinese herbal decoction combined with intravenous chemotherapy and 629 with intravenous chemotherapy alone. The results of Meta analysis showed that compared with the single intravenous chemotherapy, the decoction of traditional Chinese medicine combined with intravenous chemotherapy had statistical significance in improving the ratio of CD3 ~ +, CD4 ~ +, NK and CD4 ~ + / CD8 ~ +, ~ + No statistically significant. Conclusion: Chinese medicine decoction combined with intravenous chemotherapy can improve the cellular immune function in patients with colorectal cancer, but also need a large number of multi-center randomized controlled clinical trials to be confirmed.