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对28名正常对照组儿童、33例重度哮喘发作,19名中、轻度哮喘发作儿童,用放免法测其血浆 ET、ANF 及 cGMP 水平。并对15例重度哮喘患儿作缓解期水平测定。结果:重度哮喘发作时,ET 为87.8+3.8pg/ml,明显高于中轻度发作(47.3+3.1pg/ml)及对照组45.5±2.8pg/mi(P<0.01)。中、轻度与对照组无明显差异;血浆 ANF 水平:重度哮喘发作组为0.54±0.03ng/ml,中、轻度发作组为0.49±0.02ng/ml,对照组为0.39±0.03ng/ml,彼此间均有明显差别(P<0.01)。3组血浆 cGMP 水平彼此均有明显差别(P<0.01),且同 ANF 呈正相关(r=1.35,P<0.05).说明 ANF、ET、cGMP 均参与哮喘的发病过程;ET 升高示病情严重;ANF 与病情呈正相关.
Twenty-eight children in normal control group, 33 children with severe asthma attack and 19 children with mild or moderate asthma attacked by radioimmunoassay. Plasma levels of ET, ANF and cGMP were measured by radioimmunoassay. 15 cases of severe asthma in children with remission level measurement. Results: In the severe asthma attack, ET was 87.8 + 3.8pg / ml, which was significantly higher than that of mild episode (47.3 + 3.1pg / ml) and control group (45.5 ± 2.8pg / mi) (P <0.01). Moderate and mild seizure group was 0.49 ± 0.02ng / ml, while the control group was 0.39 ± 0.03ng / ml , There was a significant difference between them (P <0.01). Plasma cGMP levels were significantly different from each other (P <0.01), and positively correlated with ANF (r = 1.35, P <0.05), indicating that ANF, ET and cGMP are all involved in the pathogenesis of asthma; ; ANF and the disease was positively correlated.