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目的观察Ｐ物质（ＳＰ）作用于变应性鼻炎动物模型鼻粘膜引起的离子分泌改变导致的上皮表面短路电流（Ｓｈｏｒｔ－ｃｉｒｃｕｉｔｃｕｒｒｅｎｔ，Ｉｓｃ）的变化。方法以鸡蛋清蛋白致敏大鼠后，用Ｕｓｓ－ｉｎｇ室技术测定鼻粘膜上皮表面短路电流。并观察神经激肽受体（ＮＫ１）拮抗剂ＣＰ９６３４５、组胺Ｈ１受体拮抗剂吡拉明、Ｈ２受体拮抗剂雷尼替丁和河豚毒素对ＳＰ的阻断作用。结果经ＳＰ刺激，致敏大鼠鼻粘膜表面Ｉｓｃ显著增高。经四种物质预处理均能显著阻断ＳＰ引起的Ｉｓｃ变化。结论ＳＰ经感觉神经末梢释放后，可引起上皮表面离子电位变化、上皮通透性增高等一系列鼻粘膜病理变化。
Objective To observe the change of short-circuit current (Isc) caused by the change of ion secretion induced by substance P (SP) in the nasal mucosa of allergic rhinitis animal model. Methods After the sensitized rats with egg albumin, the surface epithelial short-circuit current of nasal mucosa was measured by Uss-ing chamber technique. The blocking effects of neurokinin receptor (NK1) antagonist CP96345, histamine H1 antagonist Pyridin, H2 receptor antagonist ranitidine and tetrodotoxin on SP were observed. Results After stimulated with SP, the surface of the nasal mucosa of the sensitized rats was significantly increased. Pretreatment with four substances can significantly block the change of Isc induced by SP. Conclusion After the release of sensory nerve endings, SP can cause a series of pathological changes of nasal mucosa such as changes of ion potential and epithelial permeability of epithelial surface.