用31P体内核磁共振方法无损伤地观察了C57小鼠脑在缺氧时与能量代谢有关的含磷化合物Pi，PCr，ATP的动态变化，当气体中氧气含量降到5％时，小鼠大脑的PCr，ATP逐渐减少，Pi不断增加，脑组织内pH值降低至6．83～6．93．当Pi与PCr的峰高比等于1时给予复氧，发现复氧时Pi立即降低且pH立即升高的小鼠可以恢复，反之则不可恢复，表明Pi和pH反映了大脑缺氧损伤程度． 31P nuclear magnetic resonance method was used to observe the dynamic changes of phosphorus-containing compounds Pi, PCr and ATP in C57 mouse brain during hypoxia without damage. When the content of oxygen in the gas dropped to 5%, the brain of mice Of PCr, ATP gradually decreased, Pi is increasing, the brain tissue pH value decreased to 6.83 ~ 6.93. When Pi and PCr had peak-to-peak ratio of 1, reoxygenation was found. Pi was found to be reduced immediately upon reoxygenation and instantly elevated in pH, and irreversibly on the contrary, indicating that Pi and pH reflect the extent of hypoxic injury in the brain.