论文部分内容阅读
目的 观察霉酚酸酯 (骁悉 )联合强的松治疗LN的临床疗效和不良反应。方法 4 3例狼疮性肾炎随机分为骁悉联合强的松和环磷酰胺联合强的松治疗组 ,采用ELISA、间接免疫荧光法、生化法等检测两组病人血清细胞因子IL 6、IL 8、TNF α水平 ,自身抗体 ,补体C3 、C4,肝功、肾功和尿蛋白等指标。结果 与环磷酰胺联合强的松治疗相比 ,病人经骁悉联合强的松治疗后血清IL 6、IL 8、TNF α水平 ,抗核抗体、A dsDNA抗体水平 ,血尿素氮、肌酐以及尿蛋白水平均明显降低 ;血C3 、C4增高更为明显 ,且病人无明显的骨髓抑制和肝功能损害。结论 骁悉联合强的松治疗狼疮性肾炎疗效好、安全性高 ,值得推广应用。
Objective To observe the clinical efficacy and side effects of mycophenolate mofetil and prednisone in the treatment of LN. Methods Forty-three patients with lupus nephritis were randomly divided into two groups: metformin combined with prednisone and cyclophosphamide plus prednisone. Serum cytokines IL-6 and IL-8 were detected by ELISA, indirect immunofluorescence and biochemical methods. , TNFα levels, autoantibodies, complement C3, C4, liver function, kidney function and urinary protein and other indicators. Results Compared with cyclophosphamide plus prednisone, the levels of IL-6, IL-8, TNF-alpha, anti-nuclear antibody, A dsDNA antibody, blood urea nitrogen, creatinine, Protein levels were significantly lower; blood C3, C4 increased more significantly, and the patient without significant myelosuppression and liver dysfunction. Conclusion The combination of prednisone and prednisone in the treatment of lupus nephritis is effective, safe and worthy of promotion.