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甲基强的松龙冲击疗法会导致部分病人肾功能一过性立即恶化。其原因仍有争论，为了研究这个问题，我们前瞻性观察了３０例原发性或狼疮性肾病综合征病人在甲基强的松龙冲击疗法之后早期肾功能状态。我们分别测定了冲击治疗前后血清肌酐、尿量、血清总蛋白、白蛋白和体重的变化。结果表明：２５例病人对甲基强的松龙冲击耐受良好，５例冲击前有严重低蛋白血症和血清肌酐偏高的病人，冲击后出现一过性肾功能恶化。冲击后血清肌酐与冲击前血清肌酐水平、体重和２４小时尿蛋白定量成正相关，与血清总蛋白和白蛋白成负相关。提示甲基强的松龙引起水钠潴留、导致肾间质水肿与一过性肾功能损害有关。
Methylprednisolone impact therapy can cause transient worsening of renal function in some patients. The reason there is still controversy, in order to study this issue, we prospectively observed the early renal function of 30 patients with primary or lupus nephrotic syndrome after methylprednisolone impact therapy. We measured changes in serum creatinine, urine volume, serum total protein, albumin, and body weight before and after impact treatment. The results showed that 25 patients were well tolerated with methylprednisolone. Five patients with severe hypoalbuminemia and high serum creatinine before shock had a transient worsening of renal function after shock. After shock, serum creatinine had a positive correlation with serum creatinine, body weight and 24-hour urinary protein before impact, and negatively correlated with serum total protein and albumin. Tip methylprednisolone cause sodium and water retention, resulting in renal interstitial edema and transient renal damage related.