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目的:观察奥沙利铂联合卡培他滨治疗晚期胃癌的疗效和毒副反应。方法:32例晚期胃癌均接受化疗。具体方案:奥沙利铂130mg/m2(2h静脉滴注),d1;卡培他滨2500mg/(m2·d),分早、晚2次口服,d1-14;每21d重复1次。所有病例均化疗2个周期以上,2个周期后评价疗效及毒副反应。每次化疗前检查血常规、血生化、心电图。结果:全组32例中,CR 1例,PR15例,SD 9例PD7例,总有效率为50.0%,疾病控制率为78.1%。主要毒副反应为骨髓抑制、胃肠道反应、周围神经毒性、手足综合征。结论:奥沙利铂联合卡培他滨方案治疗晚期胃癌疗效好,毒副反应可耐受。
Objective: To observe the curative effect and toxicity of oxaliplatin combined with capecitabine in the treatment of advanced gastric cancer. Methods: All 32 patients with advanced gastric cancer underwent chemotherapy. Specific programs: oxaliplatin 130mg / m2 (2h intravenous infusion), d1; capecitabine 2500mg / (m2 · d), points early and late oral twice, d1-14; every 21d repeat. All cases were more than 2 cycles of chemotherapy, 2 cycles after the evaluation of efficacy and toxicity. Before each chemotherapy check blood, blood biochemistry, electrocardiogram. Results: Of the 32 cases, CR was 1, PR 15, SD 9 and PD 7, the total effective rate was 50.0% and the disease control rate was 78.1%. The main side effects of bone marrow suppression, gastrointestinal reactions, peripheral neurotoxicity, hand-foot syndrome. Conclusion: The oxaliplatin combined with capecitabine regimen is effective in treating advanced gastric cancer and its toxicity is tolerable.