以程序性电刺激法研究安克律对犬心电生理和诱发性室性心律失常的影响。安克律引起血浓依赖性心室不应期延长和舒张期阈刺激强度增高,使QRS加宽,Q-Tc延长,高血浓使自发心率减,平均动脉血压降低。以双极电极行诱发刺激时,10例中半数可重复引起诱发性室性心律失常。然以阴极单电极行诱发刺激,则未能引起可重复的诱发性室性心律失常。表明在一定实验条件下,安克律可有易化诱发性室性心律失常的作用。 Effect of Ankle on Cardiac Electrophysiology and Induced Ventricular Arrhythmia in Programmed Electrical Stimulation. Ankle induced blood concentration-dependent ventricular refractory period and diastolic threshold stimulus intensity, so widened QRS, Q-Tc extended high blood concentration so that spontaneous heart rate decreased mean arterial pressure decreased. Induced by the bipolar electrode line stimulus, the 10 cases of half can be repeated induced evoked ventricular arrhythmias. However, the single row of cathodes induced stimulation, then failed to cause repeatable induced ventricular arrhythmias. Show that under certain experimental conditions, Ankle induces induction of ventricular arrhythmias may have the role.