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大鼠腹腔注射D—氨基半乳糖450mg.kg~(-1),引起急性肝损害,同时分别给予甘草差向异构α体和β体300ms.kg~(-1),通过光学显微镜和透射电镜观察肝组织学和肝亚微结构的变化。显示α体能明显减轻D—氨基半乳糖中毒24小时、48小时引起的肝组织和肝亚微结构的病变,而β体只能减轻中毒24小时大鼠的病变,对中毒48小时大鼠无影响。提示。体抗D—氨基半乳糖致大鼠肝损害作用优于β体。
Rats were injected intraperitoneally with D-galactosamine 450mg.kg~(-1) to induce acute hepatic injury. Glycyrrhiza epidermis isomers and β-body were also given 300ms.kg~(-1), respectively, by optical microscopy and transmission. Electron microscopy was used to observe histological changes of hepatic tissue and liver. Shows that alpha can significantly reduce liver and liver sub-microstructure lesions caused by D-aminogalactose poisoning at 24 hours and 48 hours, while beta body can only alleviate lesions in poisoned rats at 24 hours and have no effect on 48 hours of poisoned rats. . prompt. The anti-D-galactosamine induced liver damage in rats was better than the β-body.